New onset diabetes after transplant in renal transplant recipients

Abstract

Introduction: New onset diabetes after transplantation (NODAT) is a common complication of renal transplantation. Despite its prevalence and importance, the data on NODAT and its risk factors in Nepalese population are lacking and the incidence and risk factors for NODAT in Nepalese population who underwent renal transplantation at Tribhuvan University Teaching Hospital.

Methods: All the patients who underwent living donor kidney transplantation at Tribhuvan University Teaching Hospital between August, 2008 and February, 2016 were included in this study. Patients who were diagnosed with diabetes mellitus before transplantation were excluded from the study. Patients were divided into NODAT and Non-NODAT groups. Then, risk factors were compared between the two groups.

Results: A total of 350 patients who underwent living donor renal transplantation at our hospital during the study period were included. 23 patients who were diagnosed cases of Diabetes Mellitus before transplantation were excluded. In the remaining 327 cases, the incidence of NODAT was 19.57% (64 patients). Most of them (95.31%) occurred within the first 12 months’ post transplantation. The mean duration of onset of NODAT was 121.46 ± 275.58 days post transplantation. Age of the recipient greater than 45 was significantly associated with NODAT than non-NODAT patients. However, there was no statistical difference in sex between NODAT and non-NODAT patients.

Conclusion: NODAT is common complication after renal transplantation. Age of recipient > 45 years is a significant risk factor for the development of NODAT. So, we have to be more vigilant in these patients