Clinical Profile and Immediate Outcome of Children admitted in Pediatric Intensive Care Unit with the Diagnosis of Sepsis

Abstract

Background:

 Sepsis is a significant cause of death  in children. The mortality ranges from 5% to 35% from developed countries to developing countries. The information regarding predictive factors for mortality and morbidity are limited, especially in developing countries. So the aim of the study is to find out the clinical profile, immediate outcome and factors associated with poor outcome of the children with sepsis admitted in Kanti Children Hospital.

Methods

It is a retrospective study conducted at the Pediatric intensive care Unit (PICU) of   Kanti children hospital Kathmandu. The  records  of  patients  diagnosed with sepsis with clinical and laboratory parameters aged  more  than  30days  to  14 years  admitted  to  PICU of   Kanti children hospital  Kathmandu  from  13^th April 2024  to 17th September 2024  were analyzed.

Results

The most common symptom of presentation was fever (94.4%). The mortality rate of of sepsis was 26.41%. The pedictors associated with poor outcome which are statistically significant are patient requiring dialysis (P=0.016), presence of CNS disease (0.001), patient on mechanical ventilation (p=0.00) and the use of ionotropic support (0.010) and raised D-dimer (p=0.036).

Conclusion

Fever was the most common symptom of sepsis with a mortality rate was 26.41%. The predictors of poor outcome are patient requiring dialysis, presence of CNS disease, patient on mechanical ventilation, the use of ionotropic support and raised D-dimer.