Association of Ovarian Reserves with Body Mass Index, Age and Vitamin D in Infertile Females

Abstract

Introduction: Body mass index (BMI) may modulate ovarian reserve (OR) markers, and age-related fertility decline is well-established. Vitamin D has polygenetic effects on infertility, with its higher levels suggesting a positive correlation with OR markers. This study investigates the association of OR markers (AMH and FSH) with BMI, age and vitamin D in infertile females.

Methods: An analytical study was conducted at Tribhuvan University Teaching Hospital, Nepal. The association of OR markers with BMI, age and Vitamin D level were analysed in infertile females over a year.

Results: The study includes 186 infertile females, aged between 18 to 45 years. The study found no significant correlation between the OR marker (AMH) and body mass index (p = 0.92) or between OR (FSH) and BMI (p = 0.50). However, there was a significant negative correlation between age and BMI (p = 0.02). There was also a significant negative correlation between age and OR (AMH) (p = 0.04), but not between age and OR (FSH) (p = 0.09). And no significant correlation between vitamin D and OR (AMH/FSH) in infertile women, suggesting that vitamin D levels do not impact OR markers.

Conclusion: The study found no significant association between OR markers, BMI, age and vitamin D in infertile women.