Toxicity studies with acyclovir sodium in mice

Abstract

Acyclovir sodium was injected in mice in daily doses of 15 mg/kg (Gp I), 30 mg/Kg (Gp II) and 60 mg/Kg (Gp III) respectively. Mortality occurred in the Gp I and Gp II mice in the 4th week. Gp III animals died at regular intervals after day 5.

Acyclovir caused decrease in food consumption and body weight and also depression of C.N.S. in proportion to the dose administered. Isolated cases of alopecia, hemiplegia and dermatitis occurred.

Acyclovir in doses of 15 mg/Kg and 30 mg/Kg was well tolerated up to 3 weeks of daily drug administration. A dose of 60 mg/Kg was found to be toxic in mice.